Welcome to Biomaterials, Inflammation, and Tissue Engineering (BITE) Lab

We are a new research group at the F. Joseph Halcomb III, M.D. Department of Biomedical Engineering. We are interested in understanding the roles of the immune system in neotissue formation and applying this knowledge to the development of immunomodulatory biomaterials and immunotherapies for musculoskeletal and vascular regeneration. To this end, we study the role of macrophages in heterotrophic ossification (HO) and in various inflammatory conditions to elucidate their regenerative potential. We also develop microengineered biomaterial systems and immunomodulatory strategies to make cellular and molecular therapies useful in treating disease and trauma. Our research span both basic and translational research areas. 

Our team will also be collaborating with faculties at the medical school in understanding the role of inflammation in cardiovascular diseases and cancer and in developing suitable therapies.

  We are looking for energetic and passionate graduate and undergraduate students with chemical engineering, material science, mechanical engineering or biology background to join the team. Please directly email Dr. Ramkumar Annamalai for more information (more info)

We are grateful for funding from the College of Engineering and the Biomedical Engineering at the University of Kentucky. 

News

June 03, 2019

Checkout Eunjae's work on 'Bioresponsive microspheres for anti-inflammatory cytokine delivery' uploaded in bioRxiv.

Jun 06, 2019

Dr. Annamalai will be presenting our work on 'Macrophage-mediated Release of BMP2 from Bioresponsive Microspheres for Vascularize bone Regeneration' in the upcoming BMES Conference at Philadelphia.

May 05, 2019

Check out our recently published work on transport analysis of engineered liver tissue.

May 02, 2019

Our work on 'Injectable microtissues containing MSC conformally fill and repair critical-size defects' just got accepted in Biomaterials journal. This is a promising cell therapy for nonunion fractures.

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