Where Science Meets Innovation to Heal and Rebuild
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Who We Are

We’re a dynamic, interdisciplinary team in the Department of Biomedical Engineering, driven by curiosity and a shared mission: to unlock the secrets of how cells, materials, and the body’s repair mechanisms intertwine. Our passion lies in pioneering regenerative therapies that could transform lives—from healing nonunion fractures to battling chronic diseases like osteoarthritis and sarcopenia. —

Our Research: Bridging Discovery and Impact

At the TERM Lab, we explore the interplay between mechanobiology, immunology, and biomaterials to answer bold questions and engineer groundbreaking solutions:

🔬 Decoding Cellular Mechanics

• How do immune cells (e.g., macrophages) and mesenchymal stromal cells sense mechanical cues during tissue repair?
• Studying their behavior in bone healing, chronic wounds, and diseases to harness their regenerative potential.

💡 Engineering Smart Biomaterials

• Designing microengineered systems and immunomodulatory biomaterials that actively guide healing.
• Accelerating regeneration in wounds and chronic conditions.

🩺 From Bench to Bedside

• Investigating nonunion fractures, osteoarthritis, and other pathologies to develop therapies that restore function.

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Join Our Team!

Are you a curious student or researcher with a background in chemical engineering, materials science, mechanical engineering, or biology? Join us in solving puzzles at the frontier of regenerative medicine! Reach out to Dr. Ramkumar Annamalai (Email) to explore opportunities.

Funding & Support

We gratefully acknowledge support from:

• UB School of Engineering and Applied Sciences
• Centre for Clinical and Translational Sciences
• National Institutes of Health (NIAMS)
• National Institutes of Health (NIGMS)
• Orthopedic Trauma Association (OTA)

Inspiring Healing. Engineering Hope.
Let’s build the future of regenerative medicine—one discovery at a time.